Biokmod HELP

**ELEMENT** is the symbol of the element

**λ** is the radioactive decay constant, in day^{-1}. If you know the half-life T in place of **λ**, as **λ** = Log[t]/T you can write: Log[2]/T, ej.: For T = 8.2 year, then write: Log[2]/(365.24*8.2) .

**IntakeWay **choose "Injection" or "Ingestion" or "Inhalation";

**AMAD **(Activity Median Aerodynamic Diameter): (only by Inhalation) choose the value which you wish (usually AMAD = 5). Then the program will select the appropriated Initial fractional Deposition (IFD) values.

**Class** (only by Inhalation) choose: F or M or S. Then the program will select the appropriate fractional rate of absorption.

**f1**: fraction from GI (SI) to Blood. If you has chosen a Class (by inhalation), them in f1 will appear the appropiaded values for the element selected according to ICRP, but you can change this value.

**IntakeType** choose "Acute" or "Constant", "Continuous" or "MultiInputs";

- "Acute" is a single intake at t = 0,
- "Constant" (or Chronic) means a constant daily intake (all days the same).
- "Continuous" is an intake variable in the time, ej: 0.1 Exp[- 0.02 t] (not available for inhalation).
- "MultiInputs" are multi single (or acute) inputs.

**Intake**.- The input format depends on the "Intake type" chosen.

- For "Acute" write the number of Bq in t = 0
- For "Constant" write the number of Bq/day.
- For "Continuous" write {
*f*(*t)*,*t*} where f(t) is the input functions. Ej.: {0.1 Exp[- 0.02 t], t} - For "MultiInputs" write {{I
_{0}, t_{0}}, {I_{1}, t_{1}}, .... {I_{j}, t_{j}},…,{I_{n}, t_{n}}} (where I_{j}, represents the intake the day t_{j}, and t_{1}<t_{2}<..<t_{n}). Ej.: {{3, 0},{7, 3}}. The retention is given as function of t after the last intake (t_{n}=0); Note: The length of the list {{I_{0}, t_{0}},....., {I_{n}, t_{n}}} can be hundred of elements, it will be computed in a few seconds. It can be copied from a ASCII standard program (ej: Notebook)

**Output Report** choose: "IRD (Retention Fraction)" or "Retention Functions" or "GraphicsReport" , or "CompartmentContent" or "Disintegrations".

- "IRD (Retention Fraction)" gives the Lungs (only by inhation) and whole body retention , daily urine and faecal excretion for different days.
- "Retention Functions" gives the Lungs (only by inhalation) and whole body retention , daily urine and faecal excretion as function of t.
- "GraphicsReport" gives the graphics representation as function of time of the Lungs retention (only by inhalation), and the daily urine and faecal excretion, from 0 to t (chosen with"Time").
- "CompartmentContent" gives the retention in each compartment of the model as function of t.
- "Disintegrations" gives the total disintegration accumulated at time t (that is: Us or SA values).These values can be used to calculate the Dose Conversion Factors (DCFs). You will need the Dose Factors (DFs), they can be obtained from RADAR

**Time** *t* always in days. The meaning depends on the "Intake type" chosen.

- For "Acute" means time after the intake. Write
*t*(symbolic solution) or the numeric number of days (ej: 2 ). - For "Constant" means time after starting the intake. Write
*t*(symbolic solution) or the numeric number of days (ej: 2 ) - For "Continuous" means time after starting the intake. Write
*t*(symbolic solution) or the numeric number of days (ej: 2 ) - For "MultiInputs" means the time after last intake. Write
*t*(symbolic solution) or the numeric number of days (ej: 2 ).

Note: If in **Output Report** you has chosen "GraphicsReport" or "IRD (Retention Fraction)" must be chosen a numeric value for Time

**CompartNumbers and TransferRates options.- **If "True" gives a report where is indicated the relation between the number and the name of compartments, and also the Tranfer Rates. It a good idea to choose this option if in **Output Report** has been chosen "CompartmentContent" or "Disintegration".